September 12, 2009

Proteomics: Prospects and Challenges

Filed under: Bioinformatics,Computational Biology,Proteomics — Biointelligence: Education,Training & Consultancy Services @ 6:34 am

Proteomics is one of the fastest growing areas in areas of research, largely because the global-scale analysis of proteins is expected to yield more direct understanding of function and regulation than analysis of genes. Although significant advances in the comprehensive profiling, functional analysis, and regulation of proteins has occurred in model organisms such as yeast (Saccharomyces cerevisiae) and in humans, proteomics research in plants has not advanced at the same pace. The availability of the complete Arabidopsis (Arabidopsis thaliana) genome, which is small compared to that of other plants, along with an increasingly comprehensive catalog of protein-coding information from large-scale cDNA sequencing (Seki et al., 2004) and transcript mapping experiments, set it apart as a complex but accessible model organism to study plant proteomics. The application of proteomic approaches to plants entails three major challenges: (1) comprehensive identification of proteins, their isoforms, and their prevalence in each tissue; (2) characterizing the biochemical and cellular functions of each protein (3) the analysis of protein regulation and its relation to other regulatory networks. Click to read an article on Prospects of Proteomics and its challenges: