September 21, 2009

A New miRNA Knowledgebase: miRò

Filed under: Bioinformatics — Biointelligence: Education,Training & Consultancy Services @ 1:59 am
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Post Transcriptional Gene Silencing (PTGS) is a highly conserved mechanism of gene expression regulation and microRNAs (miRNAs) are its main actors. These little RNA molecules are able to bind to specific sites located in the 3′ untranslated regions (UTRs) of target transcripts, inhibiting their translation or promoting their degradation. Although much effort has demonstrated their crucial role in several physiological and pathological processes, their mechanisms of action still remain unclear.

miRò is a web-based knowledge base that provides users with miRNA–phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into a unified database equipped with an intuitive and flexible query interface and data mining facilities. The main goal of miRò is the establishment of a knowledge base which allows non-trivial analysis through sophisticated mining techniques and the introduction of a new layer of associations between genes and phenotypes inferred based on miRNAs annotations. Furthermore, a specificity function applied to validated data highlights the most significant associations.
The miRò web site is available at: