October 7, 2009

BioSytems: A New Database for Biological Systems

Filed under: Bioinformatics,Systems Biology — Biointelligence: Education,Training & Consultancy Services @ 1:08 pm
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Biological Systems are basically formed when a group of molecules interact together. A type of Biological Systems is a biological pathway. Basically a biological pathway comparises of interacting genes, proteins, and small molecules.An understanding of the components, products, and biological effects of biosystems can lead to better understanding of biological processes in normal and disease states, elucidation of possible drug effects and side effects, and other insights to complex processes that have implications for health and medicine.

NCBI has designed a BioSystems database which has a centralized access to existing pathway databases.

Current source databases supported by Biosystems database are:

1. KEGG: Kyoto Encyclopedia of Genes and Genomes ( by the Kanehisa Laboratory of the Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, Japan.

2. BioCyc ( is a collection of organism-specific pathway/genome databases (PGDBs), and the EcoCyc ( subset of BioCyc is included in the NCBI BioSystems database.

3. Reactome ( is a curated knowledge base of biological pathways, and the human subset of Reactome is included in the NCBI BioSystems database. More about the Biosystems database can be read here:

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