Biointelligence

October 22, 2009

The Structural Genomics Knowledgebase

Filed under: Bioinformatics,Computational Biology,Proteomics — Biointelligence: Education,Training & Consultancy Services @ 5:05 am
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Biology has become an increasingly data-rich subject. Many of the emerging fields of large-scale data-rich biology are designated by adding the suffix ‘-omics’ onto previously used terms. The importance to the life-science community as a whole of such large-scale approaches is reflected in the huge number of citations to many of the key papers in these fields; the human and mouse genome papers being the most obvious examples.

Well, in true sense, “Omics” is a general term for a broad discipline of science and engineering for analyzing the interactions of biological information objects in various ‘omes’. The main focus is on:
1) mapping information objects such as genes, proteins, and ligand.
2) finding interaction relationships among the objects
3) engineering the networks and objects to understand and manipulate the regulatory mechanisms
4) integrating various omes and omics subfields.

Structural Genomics is one such stream where a proper study of cellular and genetic components is performed. The RCSB Protein Data Bank (PDB) offers online tools, summary reports and target information related to the worldwide structural genomics initiatives from its portal at http://sg.pdb.org.

There are currently three components to this site:
1) Structural Genomics Initiatives contains information and links on each structural genomics site, including progress reports, target lists, target status, targets in the PDB and level of sequence redundancy.
2) Targets provides combined target information, protocols and other data associated with protein structure determination
3) Structures offers an assessment of the progress of structural genomics based on the functional coverage of the human genome by PDB structures, structural genomics targets and homology models.

This is a free, comprehensive resource produced in a collaboration between the Protein Structure Initiative (PSI) and Nature Publishing Group (NPG) and is of a great help to the scinetific research community.

More about this can be read at: http://nar.oxfordjournals.org/cgi/content/full/34/suppl_1/D302

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