March 12, 2010

XDIA: improving on the label-free data-independent analysis

Filed under: Bioinformatics — Biointelligence: Education,Training & Consultancy Services @ 12:54 pm
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XDIA is a computational strategy for analyzing multiplexed spectra acquired using electron transfer dissociation and collision-activated dissociation; it significantly increases identified spectra (250%) and unique peptides (30%) when compared with the data-dependent ETCaD analysis on middle-down, single-phase shotgun proteomic analysis. Increasing identified spectra and peptides improves quantitation statistics confidence and protein coverage, respectively.