Biointelligence

July 9, 2010

MODEVO: exploring modularity and evolution of protein interaction networks

Filed under: Bioinformatics — Biointelligence: Education,Training & Consultancy Services @ 6:16 am

Interrogating protein complexes and pathways in an evolutionary context provides insights into the formation of the basic functional components of the cell. We developed two independent Cytoscape plugins that can be cooperatively used to map evolving protein interaction networks at the module level. The APCluster plugin implements a recent affinity propagation (AP) algorithm for graph clustering and can be applied to decompose networks into coherent modules. The NetworkEvolution plugin provides the capability to visualize selected modules in consecutive evolutionary stages.

Availability: The plugins, input data and usage scenarios are freely available from the project web site: http://bioputer.mimuw.edu.pl/modevo. The plugins are also available from the Cytoscape plugin repository.

Contact: janusz@ucsd.edu

Advertisements

Leave a Comment »

No comments yet.

RSS feed for comments on this post. TrackBack URI

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: