August 3, 2009

Proteomics: Challenges and Approaches

Filed under: Bioinformatics,Proteomics — Biointelligence: Education,Training & Consultancy Services @ 9:05 am
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Proteomics is the study of the function of all expressed proteins. The term proteome was first coined to describe the set of proteins encoded by the genome1. The study of the proteome, called proteomics, now evokes not only all the proteins in any given cell, but also the set of all protein isoforms and modifications, the interactions between them, the structural description of proteins and their higher-order complexes, and for that matter almost everything ‘post-genomic’. In this overview we will use proteomics in an overall sense to mean protein biochemistry on an unprecedented, high-throughput scale.

Proteomics complements other functional genomics approaches, including microarray-based expression profiles, systematic phenotypic profiles at the cell and organism level, systematic genetics and small-molecule-based arrays. Integration of these data sets through bioinformatics will yield a comprehensive database of gene function that will serve as a powerful reference of protein properties and functions, and a useful tool for the individual researcher to both build and test hypotheses. Moreover,this large-scale data sets will be of utmost importance for the emerging field of systems biology.

Platforms for Proteomics 

Challenges and Approaches in Proteomics

Proteomics would not be possible without the previous achievements of genomics, which provided the ‘blueprint’ of possible gene products that are the focal point of proteomics studies. Some of the recent approaches used in the field of proteomics are:

1. Mass spectrometry-based proteomics

2. Array Based Proteomics

3. Structural Proteomics

4. Proteome informatics

5. Clinical Proteomics

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