Biointelligence

August 5, 2009

BioGRID: A repository useful for Systems Biology

Filed under: Bioinformatics,Systems Biology — Biointelligence: Education,Training & Consultancy Services @ 6:04 am
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Systems Biology is emerging as one of the biggest research trends these days. Talking about pathways, metabolomics, cellular cycles, interactions is common in this field.
While reading on Interaction Datasets , I came across “BioGrid”. Here is a small post on the same.
BioGRID can be explained as Biological General Repository for Interaction Datasets. It distributes collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies.
BioGRID interactions are recorded as relationships between two proteins or genes (i.e. they are binary relationships) with an evidence code that supports the interaction and a publication reference. The term “interaction” includes, as well as direct physical binding of two proteins, co-existence in a stable complex and genetic interaction. It should not be assumed that the interaction reported in BioGRID is direct and physical in nature; the experimental system definitions below indicate the nature of the supporting evidence for an interaction between the two biological entities. It should also be noted that some interactions in BioGRID have various levels of evidential support. BioGRID simply curates the result of the experiment from the publication and we do not guarantee that any individual interaction is true, well-established or the current consensus view of the community. Curating all available evidence supporting for an interaction enables orthogonal data from various sources to be collated, allowing users of the database to decide confidence in the existence and/or physiological relevance of that interaction.
More information on Biogrid can be found at: http://www.thebiogrid.org

Systems Biology is emerging as one of the biggest research trends these days. Talking about pathways, metabolomics, cellular cycles, interactions is common in this field.

While reading on Interaction Datasets , I came across “BioGrid“. Here is a small post on the same.

BioGRID can be explained as Biological General Repository for Interaction Datasets. It distributes collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies.

BioGRID interactions are recorded as relationships between two proteins or genes (i.e. they are binary relationships) with an evidence code that supports the interaction and a publication reference. The term “interaction” includes, as well as direct physical binding of two proteins, co-existence in a stable complex and genetic interaction. It should not be assumed that the interaction reported in BioGRID is direct and physical in nature; the experimental system definitions below indicate the nature of the supporting evidence for an interaction between the two biological entities. It should also be noted that some interactions in BioGRID have various levels of evidential support. BioGRID simply curates the result of the experiment from the publication and we do not guarantee that any individual interaction is true, well-established or the current consensus view of the community. Curating all available evidence supporting for an interaction enables orthogonal data from various sources to be collated, allowing users of the database to decide confidence in the existence and/or physiological relevance of that interaction.

More information on Biogrid can be found at: www.thebiogrid.org