December 2, 2009

PRGdb: The Plant Resistance Genes Database

Filed under: Bioinformatics — Biointelligence: Education,Training & Consultancy Services @ 4:26 am
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Plant disease resistance genes (R-genes) play a key role in recognizing proteins expressed by specific avirulence (Avr) genes of pathogens. R-genes originate from a phylogenetically ancient form of immunity that is common to plants and animals. However, the rapid evolution of plant immunity systems has led to enormous gene diversification. Although little is known about these agriculturally important genes, some fundamental genomic features have already been described. It has been recently shown that proteins encoded by resistance genes display modular domain structures and require several dynamic interactions between specific domains to perform their function. Some of these domains also seem necessary for proper interaction with Avr proteins and in the formation of signalling complexes that activate an innate immune response which arrests the proliferation of the invading pathogen.

PRGdb is a web accessible open-source ( database that represents the first bioinformatic resource providing a comprehensive overview of resistance genes (R-genes) in plants. PRGdb holds more than 16 000 known and putative R-genes belonging to 192 plant species challenged by 115 different pathogens and linked with useful biological information. The complete database includes a set of 73 manually curated reference R-genes, 6308 putative R-genes collected from NCBI and 10463 computationally predicted putative R-genes.

The Plant Resistance Genes (PRG) database is intended to serve as a research tool to identify and study genes involved in the disease resistance process in all plants. Data from a variety of on-line resources and literature are stored in several sections to create a unified knowledge resource with emphasis on R gene characterization and classification. The database is designed so as to allow easy integration with other data types and existing and future databases. For each cloned R gene (reference gene) is provided a fine locus annotation, reporting also homologous sequences and related disease sequences. Moreover cross links with pathogen and disease information are built, to obtain a complete view of the plant-gene-pathogen interaction system.

PRGdb is freely available here: