October 12, 2009

MISTRAL: For Multiple Protein Structure Alignment

Filed under: Bioinformatics,Computational Biology,Proteomics — Biointelligence: Education,Training & Consultancy Services @ 9:50 am
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With a rapidly growing pool of known tertiary structures, the importance of protein structure comparison parallels that of sequence alignment. Detecting structural equivalences in two or more proteins is computationally demanding as it typically entails the exploration of the combinatorial space of all possible amino acid pairings in the parent protein.

A new tool MISTRAL has been developed for multiple protein alignment based on the minimization of an energy function over the low-dimensional space of the relative rotations and translations of the molecules.

An alignment of upto 20 sequences in PDB format can be submitted at a time, where the length of each protein sequence is limited to 500 amino acids. It can be used both a standalone version or can be accessed online. MISTRAL can be accessed online here: